The Center for Intelligent Systems and Machine Learning (CISML) is a collaboration of faculty from three colleges and five academic departments at the University of Tennessee (UT) and is part of the College of Engineering on the Knoxville campus. Beginning as a simple faculty initiative to create a unified curricula, CISML evolved (in October 2010) into an official UT research center that studies the theory and application of intelligent systems and machine learning. In addition to UT faculty, the Center's research staff is comprised of six experts from Oak Ridge National Laboratory (ORNL).

CISML's focus is on designing computer-based systems that exhibit intelligent behavior, operate autonomously, and adapt to environmental changes. Examples of the diverse research activities in this area include pattern recognition, robotics, artificial intelligence, biologically-inspired cognitive architectures, bioinformatics, and data mining, to name a few.